Part:BBa_K137112

lamB

lamB is the a porin protein which is part of the maltose pathway. It is also the receptor associated and required fro lambda phage infection.

CUHK-HongKong-SBS 2024

Maltoporin, also known as the LamB protein, is a malto-oligosaccharide-selective pore protein located in the outer membrane of Escherichia coli, playing a crucial role in the transport of maltose and maltodextrins (1). It is vital for the translocation of maltodextrins that consist of more than three glucosyl units linked by alpha 1-4 bonds. The protein features a hydrophobic pathway, commonly described as a 'greasy slide,' composed of aromatic residues that assist in the guidance and selection of sugars during their passage through the channel. Furthermore, maltoporin serves as a receptor for several bacteriophages, including lambda (2).

References

1. Heine, H.-G., Kyngdon, J., & Ferenci, T. (1987). Sequence determinants in the lamB gene of Escherichia coli influencing the binding and pore selectivity of maltoporin. Gene, 53(2-3), 287–292. https://doi.org/10.1016/0378-1119(87)90018-7

2. UniProt. (2024b). P02943 · LAMB_ECOLI. Uniprot.org. https://www.uniprot.org/uniprotkb/P02943/entry

Sequence and Features

Assembly Compatibility:

• 10
  COMPATIBLE WITH RFC[10]
• 12
  COMPATIBLE WITH RFC[12]
• 21
  COMPATIBLE WITH RFC[21]
• 23
  COMPATIBLE WITH RFC[23]
• 25
  INCOMPATIBLE WITH RFC[25]

  Illegal AgeI site found at 151
  Illegal AgeI site found at 1212
  
• 1000
  COMPATIBLE WITH RFC[1000]